The present work proposes a preparation method for multilayered Au nanoparticle/silica/gadolinium compound core–shell (Au/SiO2/GdC) particles. Silica-coated Au core–shell (Au/SiO2) particles with a size of 38.0 nm were prepared by a sol-gel reaction in the presence of the Au nanoparticles with a size of 15.5 nm. Multilayered Au/SiO2/GdC particles with sizes of ca. 35–52 nm were prepared by a homogeneous precipitation reaction in the presence of Au/SiO2 particles. The computed tomography (CT) value of the Au/SiO2/GdC colloid solution containing 4.3 × 10−2 M Au was 344.1 HU: Its converted CT value (CT divided by Au concentration) was as large as 8.0 × 103 HU/M. The r1 value of the Au/SiO2/GdC colloid solution was as large as 3.5 mM−1 s−1.
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