Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity

Keita Tanita, Yoshitaka Koseki, Kazue Shimizu, Hirohito Umezawa, Hitoshi Kasai

    研究成果: Article査読

    抄録

    Nano-prodrug is a nanomedicine developed by the reprecipitation method, which allows nanoparticles to be fabricated by only prodrug molecules without using any nanocarriers. In the present study, we synthesized a heterodimer, composed of hinokitiol and podophyllotoxin (PPT) linked via different linkers of carbon chain length as new prodrug compounds, and fabricated their nano-prodrugs. We found that the longer the carbon chain linker, the smaller the size of nanoparticles, and the lower their cytotoxicity. We concluded that heterodimeric prodrugs can be fabricated into nano-prodrugs without reducing their drug loading capacity, and might eventually serve as a promising template for the development of novel nanomedicine.

    本文言語English
    ページ(範囲)79-85
    ページ数7
    ジャーナルMolecular crystals and liquid crystals
    706
    1
    DOI
    出版ステータスPublished - 2020 7 23

    ASJC Scopus subject areas

    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics

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