TY - CONF
T1 - Fabrication and characterization of biodegradable nano-particles containing a drug for DDS by self-organized precipitation method
AU - Ohsato, Daisuke
AU - Tanaka, Masaru
AU - Yamamoto, Sadaaki
AU - Higuchi, Takeshi
AU - Yabu, Hiroshi
AU - Shimomura, Masatsugu
PY - 2006/10/19
Y1 - 2006/10/19
N2 - Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).
AB - Recently, we have reported the preparation of nano-particles by mixing a poor solvent into a solution of polymer, and evaporating a good solvent. In this report, biodegradable polymer particles containing pyrene (Py) as a model compound of hydrophobic drug were fabricated. The morphology of particles was observed by FE-SEM. The content of Py in the particles was determined as c.a. 10 wt%. By measuring fluorescence spectra, we found that the Py in the particles was distributed in the state of monomer. Py was released about 80% over 200 hours in 10 mM sodium phosphate buffer (pH7.4).
KW - DDS
KW - Particles containing a drug
KW - Self-organization
UR - http://www.scopus.com/inward/record.url?scp=33749840281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749840281&partnerID=8YFLogxK
M3 - Paper
AN - SCOPUS:33749840281
T2 - 55th SPSJ Annual Meeting
Y2 - 24 May 2006 through 26 May 2006
ER -