Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

Takehiro Yamane, Kohei Makino, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi

研究成果: Article査読

20 被引用数 (Scopus)

抄録

(Chemical Equation Presented) A coordinated effort: The isomerization mechanism of prostaglandin H2 (PGH2), which is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s, was investigated using a hemethiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).

本文言語English
ページ(範囲)6438-6440
ページ数3
ジャーナルAngewandte Chemie - International Edition
47
34
DOI
出版ステータスPublished - 2008 8月 11
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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