Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

Takehiro Yamane; Kohei Makino; Naoki Umezawa; Nobuki Kato; Tsunehiko Higuchi

doi:10.1002/anie.200800137

Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

Takehiro Yamane, Kohei Makino, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi

研究成果: Article › 査読

20 被引用数 (Scopus)

抄録

(Chemical Equation Presented) A coordinated effort: The isomerization mechanism of prostaglandin H₂ (PGH₂), which is catalytically isomerized to prostacyclin or thromboxane A₂ by cytochrome P450s, was investigated using a hemethiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).

本文言語	English
ページ（範囲）	6438-6440
ページ数	3
ジャーナル	Angewandte Chemie - International Edition
巻	47
号	34
DOI	https://doi.org/10.1002/anie.200800137
出版ステータス	Published - 2008 8月 11
外部発表	はい

ASJC Scopus subject areas

触媒
化学 (全般)

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title = "Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin",

abstract = "(Chemical Equation Presented) A coordinated effort: The isomerization mechanism of prostaglandin H2 (PGH2), which is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s, was investigated using a hemethiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).",

keywords = "Cytochrome P450, Endoperoxides, Enzyme models, Heme, Ligand effects",

author = "Takehiro Yamane and Kohei Makino and Naoki Umezawa and Nobuki Kato and Tsunehiko Higuchi",

year = "2008",

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day = "11",

doi = "10.1002/anie.200800137",

language = "English",

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T1 - Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

AU - Yamane, Takehiro

AU - Makino, Kohei

AU - Umezawa, Naoki

AU - Kato, Nobuki

AU - Higuchi, Tsunehiko

PY - 2008/8/11

Y1 - 2008/8/11

N2 - (Chemical Equation Presented) A coordinated effort: The isomerization mechanism of prostaglandin H2 (PGH2), which is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s, was investigated using a hemethiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).

AB - (Chemical Equation Presented) A coordinated effort: The isomerization mechanism of prostaglandin H2 (PGH2), which is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s, was investigated using a hemethiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).

KW - Cytochrome P450

KW - Endoperoxides

KW - Enzyme models

KW - Heme

KW - Ligand effects

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

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