Extraadrenal Immunohistochemical Distribution of Steroid 21-Hydroxylase in Human

Hironobu Sasano, Nobuaki Sasano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Using an antibody against cytochrome P-450 specific for steroid 21-hydroxylase (P-45OC21), extraadrenal distribution and localization of the enzyme were immunohistochemically examined on various normal human tissues. Immunoreactive P-450C21 was demonstrated in the renal tubular system, especially in distal tubules and cortical and medullary collecting tubules : excretory ducts including intercalated ducts of the pancreas and salivary glands ; secretory ducts of the mammary glands. The immunoreactivity for P-450C21 was not present in the colon and liver. Transepithelial transport of sodium, potassium and hydrogen ions occurs in those sites where P-450C21 is present and mineralocorticoid receptors are presumed to be present. Relationship of extraadrenal 21-hydroxylase, which produces deoxycorticosterone locally, to a mineralocorticoid action is proposed.

本文言語English
ページ(範囲)21-28
ページ数8
ジャーナルthe tohoku journal of experimental medicine
154
1
DOI
出版ステータスPublished - 1988

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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