Extended affinity-guided DMAP chemistry with a finely tuned acyl donor for intracellular FKBP12 labeling

Zhining Song, Yousuke Takaoka, Yoshiyuki Kioi, Kazuhiro Komatsu, Tomonori Tamura, Takayuki Miki, Itaru Hamachi

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We successfully extended affinity-guided DMAP (AGD) chemistry with a reactivity-tuned acyl donor library that is capable of the selective and efficient labeling of FKBP12 in living cells as well as in test tube. The new AGD chemistry provides great promise for the establishment of selective intracellular protein functionalization or imaging methods.

本文言語English
ページ(範囲)333-335
ページ数3
ジャーナルChemistry Letters
44
3
DOI
出版ステータスPublished - 2015

ASJC Scopus subject areas

  • Chemistry(all)

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