Expression of the ret proto-oncogene in human medullary thyroid carcinomas and pheochromocytomas of MEN 2A.

A. Miya, M. Yamamoto, H. Morimoto, N. Tanaka, E. Shin, K. Karakawa, K. Toyoshima, Y. Ishizaka, T. Mori, S. Takai

研究成果: Article査読

40 被引用数 (Scopus)

抄録

We studied the expression of the ret proto-oncogene (proto-ret) in human medullary thyroid carcinomas (MTCs) and pheochromocytomas of multiple endocrine neoplasia type 2A (MEN 2A) by Northern blot analysis. Expression of the normal-sized transcripts was detected in all 12 MTCs and in 6 of 8 pheochromocytomas. In situ localization of proto-ret mRNA revealed that the signal was confined to the cytoplasm of MTC cells. By Southern blot analysis neither amplification nor gross genetic changes of proto-ret were found in the tumors. Although no transcripts were detected in the normal portion of the thyroid from one MEN 2A patient, faint signals were detected in normal adrenal glands by Northern blot analysis, probably due to minor populations of C-cells and chromaffin cells in specimens from which MTC and pheochromocytoma might later develop. Proto-ret may play an important role in differentiation of a specific cell lineage from neuroectoderm, and it may be involved in development of MEN 2A tumors.

本文言語English
ページ(範囲)215-219
ページ数5
ジャーナルHenry Ford Hospital medical journal
40
3-4
出版ステータスPublished - 1992
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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