TY - JOUR
T1 - Expression of the insulinoma gene rig during liver regeneration and in primary cultured hepatocytes
AU - Inoue, Chiyoko
AU - Igarashi, Kazuhiko
AU - Kitagawa, Motoo
AU - Terazono, Kimio
AU - Takasawa, Shin
AU - Obata, Ken ichi
AU - Iwata, Kazushi
AU - Yamamoto, Hiroshi
AU - Okamoto, Hiroshi
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1988/2/15
Y1 - 1988/2/15
N2 - We have isolated a novel gene, rig (rat insulinoma gene) from rat insulinomas. In the present study, rig was found to be expressed in rat regenerating liver and in primary cultured rat hepatocytes. The level of rig mRNA was increased at the proliferative phase of liver regeneration. In synchronously cultured hepatocytes, the rig mRNA level was elevated at the G1 phase of the cell cycle and the rig-protein was accumulated in the nuclei during the S phase. These results indicated that rig could be involved in a more general way in growth or cell replication.
AB - We have isolated a novel gene, rig (rat insulinoma gene) from rat insulinomas. In the present study, rig was found to be expressed in rat regenerating liver and in primary cultured rat hepatocytes. The level of rig mRNA was increased at the proliferative phase of liver regeneration. In synchronously cultured hepatocytes, the rig mRNA level was elevated at the G1 phase of the cell cycle and the rig-protein was accumulated in the nuclei during the S phase. These results indicated that rig could be involved in a more general way in growth or cell replication.
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U2 - 10.1016/0006-291X(88)90771-1
DO - 10.1016/0006-291X(88)90771-1
M3 - Article
C2 - 2829897
AN - SCOPUS:0024286906
SN - 0006-291X
VL - 150
SP - 1302
EP - 1308
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -