Expression of NUDEL in manchette and its implication in spermatogenesis

Noritaka Yamaguchi, Yasukazu Takanezawa, Hiroyuki Koizumi, Makiko Umezu-Goto, Junken Aoki, Hiroyuki Arai

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Nuclear distribution gene E-like product (NUDEL) is a mammal homologue of fungal NUDE and is involved in neuronal migration during brain development. High levels of NUDEL were expressed in murine testis as well as brain. During spermatogenesis, NUDEL was not detected until postnatal day 12 (P12), rising to significant levels at P27. NUDEL was localized predominantly along microtubules of the manchette in elongated spermatids. In maturing spermatids, NUDEL was observed only in the centrosomes, while mature testicular spermatozoa did not show any NUDEL expression. These results suggest that NUDEL plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules.

本文言語English
ページ(範囲)71-76
ページ数6
ジャーナルFEBS Letters
566
1-3
DOI
出版ステータスPublished - 2004 5月 21

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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