Expression of neutrophil gelatinase-associated lipocalin (NGAL) in peripheral nerve repair

Fatemeh Aghanasir, Hassan Aghaei, Abbas Ali Imani Fooladi, Majid Ebrahimi, Ghasem Bagherpour, Mohammad Reza Nourani

    研究成果: Article

    抜粋

    Trauma is one of the causes of peripheral nerve injuries. Free radicals increase after tissue damage. Free radicals are usually scavenged and detoxied by antioxidants. In this study, we assessed the antioxidative role of the NGAL molecule in sciatic nerve repair in rats. Materials and methods: The sciatic nerves of 40 rats were crushed and the total mRNA of samples from day 1 and 3 and week 1, 3, 5 post injury was extracted. The expression of the NGAL gene was confirmed by RT-PCR. For immunohistochemistry analysis, the samples were xed in paraformaldehyde and cut in 20 micrometer slices by cryostat. Results: The expression of NGAL signicantly upregulated in day 1, 3 and week 1 following the crushing of sciatic nerves in comparison with the intact nerves. Immunohistochemistry results also confirmed the protein expression of this gene. Discussion: The NGAL molecule showed upregulation in the degeneration process after nerve injury, so it may play an important role in nerve repair.

    元の言語English
    ページ(範囲)429-434
    ページ数6
    ジャーナルJournal of Receptors and Signal Transduction
    36
    発行部数4
    DOI
    出版物ステータスPublished - 2016 7 3

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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    Aghanasir, F., Aghaei, H., Imani Fooladi, A. A., Ebrahimi, M., Bagherpour, G., & Nourani, M. R. (2016). Expression of neutrophil gelatinase-associated lipocalin (NGAL) in peripheral nerve repair. Journal of Receptors and Signal Transduction, 36(4), 429-434. https://doi.org/10.3109/10799893.2015.1132238