Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells

Yasuka L. Yamaguchi, Satomi S. Tanaka, Miyuki Kasa, Kunio Yasuda, Patrick P.L. Tam, Yasuhisa Matsui

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts. Lrp4 is expressed in PGCs in the hindgut and the dorsal mesentery of E9.5 embryos, and in germ cells in the genital ridges of male and female E10.5-13.5 embryos. Lrp4 is also expressed in spermatogonia of the neonatal and adult testes and in the immature oocytes and follicular cells of the adult ovary. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells.

本文言語English
ページ(範囲)607-612
ページ数6
ジャーナルGene Expression Patterns
6
6
DOI
出版ステータスPublished - 2006 8

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 発生生物学

フィンガープリント

「Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル