Expression of hypothalamic corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency: A report of an autopsied case

T. Mori, Yoshio Murakami, M. Nishiki, K. Koshimura, H. Sasano, Y. Kato

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A 77-yr-old man died of metastising adenocarcinoma of the lung. He had been treated with hydrocortisone for isolated ACTH deficiency for 9 yr. At autopsy, the pituitary and the adrenal glands were atrophic. Lymphocyte infiltration was not observed in the pituitary, the adrenal and the thyroid glands. Immunohistochemistry revealed selective loss of ACTH-like immunoreactivity in the pituitary gland whereas CRH-immunoreactive cells were found in the paraventricular nucleus of the hypothalamus. This is the first report demonstrating immunohistochemical examinations of the pituitary and the hypothalamus in isolated ACTH deficiency.

本文言語English
ページ(範囲)556-559
ページ数4
ジャーナルJournal of Endocrinological Investigation
26
6
DOI
出版ステータスPublished - 2003 6
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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