Expression of GLUT-4 glucose transporter in unweighted soleus muscle of normal and STZ-induced diabetic rats

H. Ishihara, T. Asano, H. Katagiri, J. L. Lin, K. Tsukuda, K. Inukai, Y. Yazaki, Y. Oka

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Effects of 6 days of hindlimb suspension on expression of glucose transporters were studied in the skeletal muscle of nondiabetic and streptozotocin-induced diabetic rats. Although total membrane protein recovered from soleus muscles tended to decrease with suspension, GLUT-4 protein concentration (amount per gram membrane protein) was increased by 66 and 91% compared with weight-bearing control in nondiabetic and diabetic rats, respectively. Therefore, the amount of GLUT-4 protein in whole soleus muscle did not decrease with the hindlimb suspension in normal and diabetic rats. In contrast, hindlimb suspension decreased GLUT-4 mRNA amount in whole soleus muscle by 47 and 27% in nondiabetic and diabetic rats, respectively. Thus the GLUT-4 protein-to-GLUT-4 mRNA ratio was increased 2.1-fold in nondiabetic and 1.4-fold in diabetic rats. The extensor digitorum longus muscle, which generally shows little response to unweighting, exhibited no such changes. These results suggest that the amount of GLUT-4 glucose transporter in the unweighted soleus muscle was maintained via a translational and/or posttranslational mechanism in nondiabetic rats as well as in streptozotocin-induced diabetic rats under the condition of reduced weight-bearing activity.

本文言語English
ページ(範囲)E301-E307
ジャーナルAmerican Journal of Physiology - Endocrinology and Metabolism
264
2 27-2
DOI
出版ステータスPublished - 1993 1月 1
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生理学
  • 生理学(医学)

フィンガープリント

「Expression of GLUT-4 glucose transporter in unweighted soleus muscle of normal and STZ-induced diabetic rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル