Expression of class I human leukocyte antigen (HLA) and β2-microglobulin is associated with decidualization of human endometrial stromal cells

T. Komatsu, I. Konishi, M. Mandai, T. Mori, H. Hiai, M. Fukumoto

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Human leukocyte antigen (HLA) class I molecules play a central role in the immune system through either presentation of endogenous antigen and activation of T lymphocytes or functional emergence of natural killer (NK) cells. Various types of immune cells are present in the human endometrium and are believed to be involved in reproductive function and/or immunological reaction. However, little is known about the expression status and function of HLA class I molecules in the human endometrium. We therefore examined mRNA expression of HLA class I. In addition, we analysed gene expression and localization of β2-microglobulin (β2-MG), which is the non-variant chain of all HLA class I molecules. Compared with non-decidualized tissues, mRNA expression of both HLA class I and β2-MG was significantly higher in decidualized endometria in the late secretory phase, under progestin treatment and during early pregnancy. Immunohistochemical studies revealed that β2-MG was localized in decidualized endometrial stromal cells, indicating that the distribution of β2-MG is topologically correlated with that of CD56(bright+) NK cells. In-vitro culture of human endometrial stromal cells demonstrated that HLA class I mRNA was induced during the decidualization by progesterone. Accordingly, the expression of HLA class I molecules is transcriptionally activated along with decidualization of human endometrial stromal cells, and may represent an immune-endocrine function of the endometrium.

本文言語English
ページ(範囲)2246-2251
ページ数6
ジャーナルHuman Reproduction
13
8
DOI
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 生殖医学
  • 産婦人科学

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