Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry

Shinji Sato, Kumiko Jiko, Kiyoshi Ito, Nobuyoshi Ozawa, Akira Yajima, Shukichi Miyazaki, Hironobu Sasano

研究成果: Article査読

1 被引用数 (Scopus)

抄録

We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.

本文言語English
ページ(範囲)229-234
ページ数6
ジャーナルTohoku Journal of Experimental Medicine
170
4
DOI
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル