Expression of c-myc, Epidermal Growth Factor Receptor and c-erbB-2 in Human Endometrial Carcinoma and Cervical Adenocarcinoma

Shinji Sato, Kiyoshi Ito, Nobuyoshi Ozawa, Akira Yajima, Hironobu Sasano

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Thirty specimens of human endometrial carcinoma (n = 23) and cervical adenocarcinoma (n = 1) have been analyzed for c-myc, epidermal growth factor receptor (EGFR) and c-erbB-2 by immunohistochemistry. In endometrial carcinomas, expression of c-myc was observed in all cases, EGFR in 21 of 23 cases (91.3%) and c-erbB-2 in 7 of 23 cases (30.4%). In cervical adenocarcinomas, expression of c-myc was seen in 5 of 7 cases (71.6%), EGFR in all cases and c-erbB-2 in 2 of 7 cases (28.6%). c-myc immunoactivity was observed as nuclear or cytoplasmic stain or both, EGFR as membrane and cytoplasmic stain, c-erbB-2 as menbrane stain. There was no relationship between expression of these three oncogenes and clinical prognostic factors in the present study.

本文言語English
ページ(範囲)137-145
ページ数9
ジャーナルTohoku Journal of Experimental Medicine
165
2
DOI
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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