Expression of adrenomedullin mRNA in the human brain and pituitary

Kazuhiro Takahashi, Fumitoshi Satoh, Masahiko Sone, Osamu Murakami, Hironobu Sasano, Toraichi Mouri, Shigeki Shibahara

研究成果: Article査読

58 被引用数 (Scopus)

抄録

We have recently reported the presence of immunoreactive (IR) adrenomedullin (ADM) in the human brain. In the present study, the expression of ADM mRNA was studied by Northern blot analysis in the human brain and pituitary, and the presence of IR-ADM in the human pituitary was studied by radioimmunoassay. ADM mRNA was clearly detected in every region of the brain examined and in the pituitary. High concentrations of IR-ADM were present in the whole pituitary (16.7 ± 2.0 pmol/g wet weight, mean ± SEM, n = 4). Reverse phase high performance liquid chromatography of the pituitary showed a peak eluting in the position of human ADM(1-52). These findings suggest that ADM acts as a neuromodulator or a neurotransmitter in the brain, and as an autocrine factor, a paracrine factor, or a neurohormone in the pituitary.

本文言語English
ページ(範囲)1051-1053
ページ数3
ジャーナルPeptides
18
7
DOI
出版ステータスPublished - 1997

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

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