Expression, function, and clinical implications of the estrogen receptor β in human lung cancers

Yoko Omoto, Eiju Tsuchiya, Hidetaka Eguchi, Shin ichi Hayashi, Yasuhito Kobayashi, Yoko Omoto, Takao Yamori, Hirotaka Iwase, Ken Nakagawa, Yuichi Ishikawa, Margaret Warner, Jan Åke Gustafsson, Margaret Warner, Jan Åke Gustafsson

研究成果: Article査読

182 被引用数 (Scopus)


The higher frequency of human lung adenocarcinoma in females than in males, strongly suggests the involvement of gender dependent factors in the etiology of this disease. This is the first investigation of estrogen receptor (ER) β in human lung. Immunohistochemical staining revealed ERβ expression in normal lung and in atypical adenomatous hyperplasia (AAH), considered as a precancerous lesion for adenocarcinomas. Adenocarcinomas showed significantly higher expression of ERβ than squamous cell carcinomas. On the contrary, ERα expression was not detected in all cases. The functional integrity of ERβ such as the binding ability to estrogen responsive element (ERE) and transcriptional activity was confirmed using a human lung cancer cell line, RERF-LC-OK. Colony formation of this cell was significantly reduced in the presence of pure antiestrogen. We conclude that ERβ, but not ERα, is present in lung tissues with an important physiological function in normal lung. Furthermore, ERβ may play a role in growth and development of adenocarcinomas.

ジャーナルBiochemical and biophysical research communications
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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