Experimental study for cancer diagnosis with positron-labeled fluorinated glucose analogs: [18F]-2-fluoro-2-deoxy-D-mannose: A new tracer for cancer detection

Hiroshi Fukuda, Taiju Matsuzawa, Yoshinao Abe, Satoshi Endo, Kenji Yamada, Kazuo Kubota, Jun Hatazawa, Tachio Sato, Masatoshi Ito, Toshihiro Takahashi, Ren Iwata, Tatsuo Ido

研究成果: Article査読

63 被引用数 (Scopus)

抄録

18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and 18F-2-fluoro-2-deoxy-D-mannose (18F-FDM) were tested as tumor diagnostic agents in a transplantable rat tumor and rabbit tumors. Tissue distribution studies in rats showed high tumor uptakes of both radiopharmaceuticals. The tumor uptake reached 2.65±0.61% dose 18F-FDG/g and 2.65±0.81% dose 18F-FDM/g at 60 min and remained relatively constant until 120 min. Blood clearance of both 18F-FDG and 28F-FDM was very rapid and tumor-to-blood ratios reached 22.1 and 29.4 at 60 min, respectively. Tumor-to-tissue ratios of both radiopharmaceuticals were very high in most organs, especially in the liver, kidney, and pancreas. Positron emission tomography (PET) of rabbit tumor with 18F-FDM clearly delineated the main tumor, central necrosis, and lymph node metastases. These data suggested that 18F-FDM which is a by-product of 18F-FDG synthesis, was also an excellent cancer diagnostic agent as well as 18F-FDG. This is not only a new feature of 18F-FDM, but also an economical improvement on cancer diagnosis by PET.

本文言語English
ページ(範囲)294-297
ページ数4
ジャーナルEuropean Journal of Nuclear Medicine
7
7
DOI
出版ステータスPublished - 1982 7 1

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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