Exogenous glucocorticoid eliminates or reverses circadian blood pressure variations

Yutaka Imai, Keishi Abe, Shuichi Sasaki, Naoyoshi Minami, Masanori Munakata, Minoru Nihei, Hiroshi Sekino, Kaoru Yoshinaga

研究成果: Article査読

83 被引用数 (Scopus)


The effect of glucocorticoid on circadian variations of blood pressure was examined. In untreated patients with essential hypertension, a clear nocturnal fall in blood pressure and heart rate was observed and this was unaffected by combined treatment with antihypertensive drugs. The circadian blood pressure variation in patients with chronic glomerulonephritis (CGN) not receiving glucocorticoid treatment was essentially the same as that in patients with essential hypertension. In both groups there was a positive correlation between blood pressure and heart rate. On the other hand, In patients with CGN and systemic lupus erythematosus (SLE) who were treated with glucocorticoid, there was no nocturnal fall In blood pressure, and often a significant rise. In these patients the blood pressure was lowest in the afternoon and began to rise from then, and during the night, attaining a peak level in the morning. Despite this changed pattern of blood pressure variations, the heart rate in these patients was clearly reduced at night. In 10 patients with CGN and SLE, circadian rhythm of blood pressure and heart rate was examined before and during treatment with prednisolone (40.2 ± 17.0 mg/day for 58.0 ± 19.4 days, mean ± s.d.). Prednisolone abolished the nocturnal fall of blood pressure, while the nocturnal fall of heart rate remained. There was no correlation between blood pressure and heart rate in patients with glucocorticoid treatment. These results suggest that the circadian blood pressure variation is Influenced by the hypothalmo-pituitary-adrenal axis, probably through Its action on the autonomic nervous system.

ジャーナルJournal of hypertension
出版ステータスPublished - 1989 2

ASJC Scopus subject areas

  • 内科学
  • 生理学
  • 循環器および心血管医学


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