Excitatory interaction between glutamate receptors and protein kinases

T. R. Soderling, S. E. Tan, E. McGlade‐McCulloh, H. Yamamoto, K. Fukunaga

研究成果: Article査読

49 被引用数 (Scopus)

抄録

One of the most active areas of neurobiology research concerns mechanisms involved in paradigms of synaptic plasticity. A popular model for cellular leaning and memory is long term potentiation (LTP) in hippocamus. LTP requires postsynaptic influx of Ca2+ which triggers multiple biochemical pathways resulting in pre‐ and postsynaptic mechanisms enhancing long term synaptic efficiency. This article focuses on an acute postsynaptic Mechanism that can enhance responsiveness of glutamate receptors. Evidence is presented that calcium/calmodulin/dependent protein kinase II, the major potsynaptic density protein at excitatory glutaminergic synapses, can phosphorylate glutamate receptors and enhance ion current flowing through them. 1994 John Wiley & Sons, Inc.

本文言語English
ページ(範囲)304-311
ページ数8
ジャーナルJournal of Neurobiology
25
3
DOI
出版ステータスPublished - 1994 3
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 細胞および分子神経科学

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