Excitation of autonomic nerves by 4-aminopyridine in the isolated, blood-perfused sino-atrial node preparation of the dog

Teruyuki Yanagisawa, Keisuke Satoh, Norio Taira

研究成果: Article査読

23 被引用数 (Scopus)

抄録

4-Aminopyridine injected into the sinus node artery produced a long-lasting decrease in sinus rate preceded by a transient increase. With a large dose, a long-lasting increase in sinus rate was superimposed on the long-lasting decrease phase. The long-lasting decrease and increase in sinus rate were abolished by 1-hyoscyamine and propranolol respectively, and both were reduced by tetrodotoxin. These results can be interpreted as being due to excitation of autonomic nerves by 4-aminopyridine.

本文言語English
ページ(範囲)189-192
ページ数4
ジャーナルEuropean Journal of Pharmacology
49
2
DOI
出版ステータスPublished - 1978 5 15

ASJC Scopus subject areas

  • 薬理学

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