Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization

Hafumi Nishi, Kosuke Hashimoto, Thomas Madej, Anna R. Panchenko

研究成果: Chapter

27 被引用数 (Scopus)

抄録

Protein homooligomers afford several important benefits for the cell; they mediate and regulate gene expression, activity of many enzymes, ion channels, receptors, and cell-cell adhesion processes. The evolutionary and physical mechanisms of oligomer formation are very diverse and are not well understood. Certain homooligomeric states may be conserved within protein subfamilies and between different subfamilies, therefore providing the specificity to particular substrates while minimizing interactions with unwanted partners. In addition, transitions between different oligomeric states may regulate protein activity and support the switch between different pathways. In this chapter, we summarize the biological importance of homooligomeric assemblies, physicochemical properties of their interfaces, experimental methods for their identification, their evolution, and role in human diseases.

本文言語English
ホスト出版物のタイトルOligomerization in Health and Disease
出版社Elsevier B.V.
ページ3-24
ページ数22
ISBN(印刷版)9780123869319
DOI
出版ステータスPublished - 2013
外部発表はい

出版物シリーズ

名前Progress in Molecular Biology and Translational Science
117
ISSN(印刷版)1877-1173

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学

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