Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells

Hiroshi Matsunaga, Naohida Yamashita, Yoshio Maruyama, Itaru Kojima, Kiyoshi Kurokawa

研究成果: Article査読

36 被引用数 (Scopus)

抄録

We analyzed inward Ca2+ currents in single bovine adrenal glomerulosa cell using whole-cell patch clamp techniques. Two types of voltage-gated Ca2+ channel currents were identified. One was a transient (T) type which decayed within 100 ms, characterized by a low threshold voltage (about -70 mv) similar to that seen in rat adrenal glomerulosa cells (Matsunaga, H. et al. (1987) Pflügers Arch. 408, 351-355.) Another was a long-lasting (L) type which shows a more positive threshold potential. The present results suggest that while T type Ca2+ channels may explain initial calcium influx in response to an elevation in extracellular K+, L type Ca2+ channels may allow sustained calcium influx which is necessary for sustained aldosterone secretion.

本文言語English
ページ(範囲)1049-1054
ページ数6
ジャーナルBiochemical and biophysical research communications
149
3
DOI
出版ステータスPublished - 1987 12月 31

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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