@article{5798b5028bb54980816c8beaf2808b4b,
title = "Evidence for an enolate mechanism in the asymmetric Michael reaction of α,β-unsaturated aldehydes and ketones: Via a hybrid system of two secondary amine catalysts",
abstract = "The key nucleophile was found to be neither an enamine nor an enol, but an enolate in the direct Michael reaction of α,β-unsaturated aldehydes and non-activated ketones catalyzed by two amine catalysts namely diphenylprolinol silyl ether and pyrrolidine. This is a rare example of an enolate from a ketone serving as a key intermediate in the asymmetric organocatalytic reaction involving secondary amine catalysts because the ketone enolates are generally generated using a strong base, and the enamine is a common nucleophile in this type of reaction.",
author = "Nariyoshi Umekubo and Takahiro Terunuma and Eunsang Kwon and Yujiro Hayashi",
note = "Funding Information: We thank Prof. Tohru Fukuyama for the discussion about the generation of enolates from ketones and secondary amines. We thank reviewers for the useful comments. We thank Mr Amae-chi Shedrack Odoh in my group for the English corrections. This work was supported by JSPS KAKENHI Grant Number JP20H04801 in Hybrid Catalysis for Enabling Molecular Synthesis on Demand, and JP19H05630. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2020",
month = nov,
day = "7",
doi = "10.1039/d0sc03359f",
language = "English",
volume = "11",
pages = "11293--11297",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "41",
}