Evaluation of functionally weighted dose-volume parameters for thoracic stereotactic ablative radiotherapy (SABR) using CT ventilation

Takayuki Kanai, Noriyuki Kadoya, Yujiro Nakajima, Yuya Miyasaka, Yoshiro Ieko, Tomohiro Kajikawa, Kengo Ito, Takaya Yamamoto, Suguru Dobashi, Ken Takeda, Kenji Nemoto, Keiichi Jingu

研究成果: Article査読

3 被引用数 (Scopus)


For the purpose of reducing radiation pneumontisis (RP), four-dimensional CT (4DCT)-based ventilation can be used to reduce functionally weighted lung dose. This study aimed to evaluate the functionally weighted dose-volume parameters and to investigate an optimal weighting method to realize effective planning optimization in thoracic stereotactic ablative radiotherapy (SABR). Forty patients treated with SABR were analyzed. Ventilation images were obtained from 4DCT using deformable registration and Hounsfield unit-based calculation. Functionally-weighted mean lung dose (fMLD) and functional lung fraction receiving at least x Gy (fVx) were calculated by two weighting methods: thresholding and linear weighting. Various ventilation thresholds (5th-95th, every 5th percentile) were tested. The predictive accuracy for CTCAE grade ≧ 2 pneumonitis was evaluated by area under the curve (AUC) of receiver operating characteristic analysis. AUC values varied from 0.459 to 0.570 in accordance with threshold and dose-volume metrics. A combination of 25th percentile threshold and fV30 showed the best result (AUC: 0.570). AUC values with fMLD, fV10, fV20, and fV40 were 0.541, 0.487, 0.548 and 0.563 using a 25th percentile threshold. Although conventional MLD, V10, V20, V30 and V40 showed lower AUC values (0.516, 0.477, 0.534, 0.552 and 0.527), the differences were not statistically significant. fV30 with 25th percentile threshold was the best predictor of RP. Our results suggested that the appropriate weighting should be used for better treatment outcomes in thoracic SABR.

ジャーナルPhysica Medica
出版ステータスPublished - 2018 5月

ASJC Scopus subject areas

  • 生物理学
  • 放射線学、核医学およびイメージング
  • 物理学および天文学(全般)


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