Evaluation of Exercise-Induced Organ Energy Metabolism Using Two Analytical Approaches: A PET Study

Mehedi Masud, Toshihiko Fujimoto, Masayasu Miyake, Shoichi Watanuki, Masatoshi Itoh, Manabu Tashiro

研究成果: Conference contribution

抄録

Our purpose was to evaluate exercise-induced organ glucose metabolism using 18F-2-fluoro-2-deoxyglucose ([18F]FDG and three-dimensional positron emission tomography technique (3D-PET), comparing two analytical procedures. Eleven healthy male subjects were studied as controls (n=6) and exercise group (n=5). Exercise group subjects performed ergometer bicycle exercise for 40 minutes at 40% and 70% VSO2max. [18F]FDG (39.2 2.6 MBq) was injected 10 min after exercise. A whole body 3D-PET scan was performed immediately after exercise using PET scanner (SET-2400W, Shimadzu Co. Kyoto, Japan). PET image data was reconstructed by filtered 3D back projection algorithm with supercomputer (SX-4/128H4, Synergy Center, Tohoku Univ). Controls were studied using identical study criteria with exercise group. Two analytical procedures, semiquantitative (standardized uptake value; SUV) and quantitative (regional metabolic rate of glucose; rMRGlc) [Autoradiographic method (Phelps et al.)] were applied to assess organ glucose metabolism. ROIs (regions of interest) were drawn on lower limb muscles (e.g., thigh and lumbar/gluteal muscles) and viscera (e.g., liver, heart and brain). To compare analytical procedures, correlation coefficient analysis was done between SUV and rMRGlc data of lower limb muscles, brain and heart. Quantitative analysis revealed that rMRGlc was increased (p<0.05) in skeletal muscles of thigh and lumbar/gluteal region, and decreased in brain (p<0.05) at mild or moderate exercise loads. Semiquantitative analysis revealed the identical results except in lumbar/gluteal muscles. It was found a correlation between SUV and rMRGlc at thigh, brain and heart, however; correlation was not suggestive at lumbar/gluteal muscles. We validated the semiquantitative procedure (SUV) taking absolute quantification method of glucose metabolic rate as a standard. It was observed, the rMRGlc was increased in thigh muscles and decreased in brain at mild or moderate workloads. However, discrepancies between SUV and rMRGlc in one organ demonstrate, semiquantitative approach needs a great care when metabolic rate of glucose utilization changes at wholebody level.

本文言語English
ホスト出版物のタイトル13th International Conference on Biomedical Engineering - ICBME 2008
ページ2204-2206
ページ数3
DOI
出版ステータスPublished - 2009 12 1
イベント13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
継続期間: 2008 12 32008 12 6

出版物シリーズ

名前IFMBE Proceedings
23
ISSN(印刷版)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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