Evaluation of combinations of 4=-ethynyl-2-fluoro-2=-deoxyadenosine with clinically used antiretroviral drugs

Atsuko Hachiya, Aaron B. Reeve, Bruno Marchand, Eleftherios Michailidis, Yee Tsuey Ong, Karen A. Kirby, Maxwell D. Leslie, Shinichi Oka, Eiichi N. Kodama, Lisa C. Rohan, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos

研究成果: Article

13 被引用数 (Scopus)

抄録

Drug combination studies of 4=-ethynyl-2-fluoro-2=-deoxyadenosine (EFdA) with FDA-approved drugs were evaluated by two different methods, MacSynergy II and CalcuSyn. Most of the combinations, including the combination of the two adenosine analogs EFdA and tenofovir, were essentially additive, without substantial antagonism or synergism. The combination of EFdA and rilpivirine showed apparent synergism. These studies provide information that may be useful for the design of EFdA combination regimens for initial and salvage therapy assessment.

本文言語English
ページ(範囲)4554-4558
ページ数5
ジャーナルAntimicrobial agents and chemotherapy
57
9
DOI
出版ステータスPublished - 2013 9

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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