抄録
To evaluate the potential effect of estrogens in premenopausal female thyroid cancer, the concentrations of 14 estrogens were quantitatively determined in the urine of pre- and post-operative patients with thyroid papillary cancer (18 patients case, 26∼54 years) and normal female subjects (20 cases, 31∼52 years). The highly sensitive gas chromatography-mass spectrometry-selected ion-monitoring method was used for estrogens analysis. And an estrogen-oxidative metabolism and 16α-hydroxyestrone to 2-hydroxyestrone (16α-OH E1/2-OH E1) which is the two primary and competing site of estrogen-oxidation, were determined. Catechol estrogens, including 2-OH E1, were also increased without significant changes of the other estrogen metabolites in pre-operative patients with thyroid papillary cancer compared with normal subjects. The lowest mean value of 16α-OH E1/2-OH E1 was remarked in pre-operative patients, and it was significantly different from the ratio of post-operative cases. As a result, it is suggested that the increase of 2-hydroxylation in estrogen metabolism may have a significant association with female thyroid cancer.
本文言語 | English |
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ページ(範囲) | 27-32 |
ページ数 | 6 |
ジャーナル | Cancer Letters |
巻 | 189 |
号 | 1 |
DOI | |
出版ステータス | Published - 2003 1月 10 |
外部発表 | はい |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究