Estrogens and polyamines in breast cancer: Their profiles and values in disease staging

Seon Hwa Lee, Soon Ok Kim, Hy De Lee, Bong Chul Chung

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The urinary concentrations of 16 estrogens and 11 polyamines were quantitatively determined by gas chromatography-mass spectrometry and gas chromatography with nitrogen-phosphorus detection. Samples from patients with stages I-IV of breast cancer (35 cases, aged 27-65 years) as well as from age-matched normal female subjects (25 cases, aged 22-61 years) were tested. Also, the ratios of precursor to product metabolite including 16α-OH E1 to 2-OH E1, which are linked to estrogen and polyamine biosynthetic pathways, were determined to explore enzyme involvement in breast cancer and to evaluate the potential usefulness of these ratios and concentrations as disease staging markers. It was confirmed that major estrogens and 16α-OH E1 were positively associated with breast cancer and catechol estrogens including 2-OH E1 were inversely associated with breast cancer. The ratios of N1-acSp/Spd and 16α-OH E1/2-OH E1 might be a useful dual marker for staging of breast cancer. From the variation of the relative ratios of polyamines, it is suggested that alteration in polyamine oxidase (PAO) activity may play an important role in the development of breast cancer. Copyright (C) 1998 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)47-56
ページ数10
ジャーナルCancer Letters
133
1
DOI
出版ステータスPublished - 1998 11 13
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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