Estrogen-related cancer microenvironment of breast carcinoma

Yuri Yamaguchi, Shin Ichi Hayashi

研究成果: Review article査読

29 被引用数 (Scopus)

抄録

Stromal cells establish the microenvironment based on interaction with tumor cells, which is essential for cancer growth, invasion and metastasis. Fibroblasts are the primary component of stroma, and carcinoma-associated fibroblasts (CAFs) demonstrate tumor-promoting activities compared with normal counterparts. In breast cancers, stromal fibroblasts adjacent to the tumor express aromatase, a key enzyme in the synthesis of estrogen, resulting in in situ estrogen production, and aromatase is a primary target of endocrine therapy. Thus, stromal fibroblasts demonstrate multiple functions in the genesis and progression of breast cancers. In this paper, we discuss the importance of tumor-stromal crosstalk in breast cancers, and describe our system to predict the efficacy of endocrine therapy and to analyze estrogen signals in individual breast cancers.

本文言語English
ページ(範囲)1-7
ページ数7
ジャーナルendocrine journal
56
1
DOI
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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