Estimation of size of red blood cell aggregates using backscattering property of high-frequency ultrasound: In vivo evaluation

Yusaku Kurokawa, Hirofumi Taki, Satoshi Yashiro, Kan Nagasawa, Yasushi Ishigaki, Hiroshi Kanai

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We propose a method for assessment of the degree of red blood cell (RBC) aggregation using the backscattering property of high-frequency ultrasound. In this method, the scattering property of RBCs is extracted from the power spectrum of RBC echoes normalized by that from the posterior wall of a vein. In an experimental study using a phantom, employing the proposed method, the sizes of microspheres 5 and 20μm in diameter were estimated to have mean values of 4.7 and 17.3μm and standard deviations of 1.9 and 1.4 μm, respectively. In an in vivo experimental study, we compared the results between three healthy subjects and four diabetic patients. The average estimated scatterer diameters in healthy subjects at rest and during avascularization were 7 and 28 μm, respectively. In contrast, those in diabetic patients receiving both antithrombotic therapy and insulin therapy were 11 and 46 μm, respectively. These results show that the proposed method has high potential for clinical application to assess RBC aggregation, which may be related to the progress of diabetes.

本文言語English
論文番号07KF12
ジャーナルJapanese journal of applied physics
55
7
DOI
出版ステータスPublished - 2016 7

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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