Estimation of possible errors in DNA computing

Yohei Aoi, Tatsuo Yoshinobu, Katsuyuki Tanizawa, Kozo Kinoshita, Hiroshi Iwasaki

研究成果: Article

抄録

DNA computing is a novel method of computing proposed by L. M. Adleman [Science 266 (1994) 1021], in which the data is encoded in the sequences of oligonucleotides. Massively parallel reactions between oligonucleotides are expected to make it possible to solve huge problems. In this study, reliability of the ligation process employed in the DNA computing is tested by estimating the error rate at which wrong oligonucleotides are ligated. Ligation of wrong oligonucleotides would result in a wrong answer in the DNA computing. The dependence of the error rate on the number of mismatches between oligonucleotides and on the combination of bases is investigated.

本文言語English
ページ(範囲)301-307
ページ数7
ジャーナルTechnology Reports of the Osaka University
48
2319-2337
出版ステータスPublished - 1998 10 15
外部発表はい

ASJC Scopus subject areas

  • Engineering(all)

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