Estimation of age from sclerotic glomeruli

Naoki Fukuda; Yoichi Suzuki; Kaoru Sato; Daisuke Yajima; Mutsumi Hayakawa; Hisako Motani; Kazuhiro Kobayashi; Katsura Otsuka; Sayaka Nagasawa; Hirotaro Iwase

doi:10.1016/j.forsciint.2009.12.062

Estimation of age from sclerotic glomeruli

Naoki Fukuda, Yoichi Suzuki, Kaoru Sato, Daisuke Yajima, Mutsumi Hayakawa, Hisako Motani, Kazuhiro Kobayashi, Katsura Otsuka, Sayaka Nagasawa, Hirotaro Iwase

東北メディカル・メガバンク機構

研究成果: Article › 査読

3 被引用数 (Scopus)

抄録

Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36×APSG (APSG: arcsine-transformed PSG). The R² value of the regression line was 0.598.The diagnostic test with the PSG value (cutoff = 0.6%) for the age stratum (cutoff = 33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.

本文言語	English
ページ（範囲）	123.e1-123.e4
ジャーナル	Forensic Science International
巻	197
号	1-3
DOI	https://doi.org/10.1016/j.forsciint.2009.12.062
出版ステータス	Published - 2010 4月

ASJC Scopus subject areas

病理学および法医学
法学

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10.1016/j.forsciint.2009.12.062

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title = "Estimation of age from sclerotic glomeruli",

abstract = "Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36×APSG (APSG: arcsine-transformed PSG). The R2 value of the regression line was 0.598.The diagnostic test with the PSG value (cutoff = 0.6%) for the age stratum (cutoff = 33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.",

keywords = "Age estimation, Forensic pathology, Sclerotic glomeruli, Statistical analysis",

author = "Naoki Fukuda and Yoichi Suzuki and Kaoru Sato and Daisuke Yajima and Mutsumi Hayakawa and Hisako Motani and Kazuhiro Kobayashi and Katsura Otsuka and Sayaka Nagasawa and Hirotaro Iwase",

year = "2010",

month = apr,

doi = "10.1016/j.forsciint.2009.12.062",

language = "English",

volume = "197",

pages = "123.e1--123.e4",

journal = "Forensic Science International",

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T1 - Estimation of age from sclerotic glomeruli

AU - Fukuda, Naoki

AU - Suzuki, Yoichi

AU - Sato, Kaoru

AU - Yajima, Daisuke

AU - Hayakawa, Mutsumi

AU - Motani, Hisako

AU - Kobayashi, Kazuhiro

AU - Otsuka, Katsura

AU - Nagasawa, Sayaka

AU - Iwase, Hirotaro

PY - 2010/4

Y1 - 2010/4

N2 - Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36×APSG (APSG: arcsine-transformed PSG). The R2 value of the regression line was 0.598.The diagnostic test with the PSG value (cutoff = 0.6%) for the age stratum (cutoff = 33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.

AB - Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36×APSG (APSG: arcsine-transformed PSG). The R2 value of the regression line was 0.598.The diagnostic test with the PSG value (cutoff = 0.6%) for the age stratum (cutoff = 33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.

KW - Age estimation

KW - Forensic pathology

KW - Sclerotic glomeruli

KW - Statistical analysis

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SP - 123.e1-123.e4

JO - Forensic Science International

JF - Forensic Science International

SN - 0379-0738

IS - 1-3

ER -

Estimation of age from sclerotic glomeruli

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