Essential role of DAP12 signaling in macrophage programming into a fusion-competent state

Laura Helming, Elena Tomasello, Themis R. Kyriakides, Fernando O. Martinez, Toshiyuki Takai, Siamon Gordon, Eric Vivier

研究成果: Article

75 引用 (Scopus)

抜粋

Multinucleated giant cells, formed by fusion of macrophages, are a hallmark of granulomatous inflammation. With a genetic approach, we show that signaling through the adaptor protein DAP12 (DNAX activating protein of 12 kD), its associated receptor triggering receptor expressed by myeloid cells 2 (TREM-2), and the downstream protein tyrosine kinase Syk is required for the cytokineinduced formation of giant cells and that overexpression of DAP12 potentiates macrophage fusion. We also present evidence that DAP12 is a general macrophage fusion regulator and is involved in modulating the expression of several macrophage-associated genes, including those encoding known mediators of macrophage fusion, such as DC-STAMP and Cadherin 1. Thus, DAP12 is involved in programming of macrophages through the regulation of gene and protein expression to induce a fusion-competent state.

元の言語English
記事番号ra11
ジャーナルScience Signaling
1
発行部数43
DOI
出版物ステータスPublished - 2008 10 28

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Helming, L., Tomasello, E., Kyriakides, T. R., Martinez, F. O., Takai, T., Gordon, S., & Vivier, E. (2008). Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Science Signaling, 1(43), [ra11]. https://doi.org/10.1126/scisignal.1159665