Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress

Pisut Katavetin, Reiko Inagi, Toshio Miyata, Jing Shao, Ryoji Sassa, Stephen Adler, Nobuaki Eto, Hideki Kato, Toshiro Fujita, Masaomi Nangaku

研究成果: Article

76 引用 (Scopus)

抜粋

Recent studies have established that erythropoietin (EPO) is a pleiotropic cytokine. In this study we investigated whether pleiotropic effects of EPO may involve regulation of heme oxygenase (HO)-1, an anti-oxidative stress protein. A stimulatory effect of EPO on HO-1 expression was demonstrated in cultured renal endothelial cells, in which EPO decreased intracellular oxidative stress and provided cytoprotection against H2O2. These beneficial effects were partially reversed by a HO-1 inhibitor. We then evaluated whether EPO induces HO-1 and ameliorates renal injury in vivo. Administration of EPO to Dahl salt-sensitive (DS) rats with low salt diet, a model of chronic tubulointerstitial injury, reduced proteinuria, and renal injury including peritubular capillaries rarefaction as compared to vehicle-treated DS rats. This renoprotection was associated with up-regulation of HO-1 in the kidney. In conclusion, EPO-induced HO-1 expression is likely to provide cytoprotection against oxidative stress.

元の言語English
ページ(範囲)928-934
ページ数7
ジャーナルBiochemical and biophysical research communications
359
発行部数4
DOI
出版物ステータスPublished - 2007 8 10
外部発表Yes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Katavetin, P., Inagi, R., Miyata, T., Shao, J., Sassa, R., Adler, S., Eto, N., Kato, H., Fujita, T., & Nangaku, M. (2007). Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress. Biochemical and biophysical research communications, 359(4), 928-934. https://doi.org/10.1016/j.bbrc.2007.05.207