Epigenetic regulation for the induction of meiosis

Y. Matsui, K. Hayashi

研究成果: Short survey査読

13 被引用数 (Scopus)

抄録

The germ cell lineage is the sole cell lineage through which genomic information is transmitted into successive generations. To this end, germ cells undergo various specific differentiation steps including meiosis, whose regulation seems to correlate closely with fundamental mechanisms that create differences between germ cells and somatic cells. In mammals, meiosis is triggered by extra-embryonic stimuli such as retinoic acid, which may induce various intracellular molecular cascades promoting meiosis. In addition, the specific epigenetic status arranged in germ cells before and after induction of meiosis, including meiosis-specific transcription control based on histone methylation by a novel histone methyltransferase Meisetz, is also critical for its proper progression.

本文言語English
ページ(範囲)257-262
ページ数6
ジャーナルCellular and Molecular Life Sciences
64
3
DOI
出版ステータスPublished - 2007 2

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 薬理学
  • 細胞および分子神経科学
  • 細胞生物学

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