Epidemiology and genetic characterization of noroviruses among adults in an endemic setting, Peruvian Amazon Basin, 2004-2011

Sarah Blythe Ballard, Erik J. Reaves, C. Giannina Luna, Maria E. Silva, Claudio Rocha, Kristen Heitzinger, Mayuko Saito, Sonia Apaza, Susan Espetia, David L. Blazes, Drake H. Tilley, Rene C.Guzmán Aguilar, Robert H. Gilman, Daniel G. Bausch

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Background: Successful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries (LMIC). Materials and Methods: We conducted a nested case-control study within a Peruvian military cohort to characterize the burden of norovirus infection, predominant genotypes, and associated symptoms from 2004 through 2011. Randomly selected case and control stools were tested for norovirus, bacteria, and parasites. The odds ratio of the association between norovirus infection and diarrhea was estimated using multiple logistic regression and co-infection adjusted attributable fractions were calculated. Results: Of the 3,818 cohort study participants, 624 developed diarrhea. Overall and norovirus-associated diarrhea incidence rates were 42.3 and 6.0 per 100 person-years, respectively. The most prevalent norovirus genogroup was GII (72.5%, 29/40), which was associated with diarrhea (AOR 3.4, 95% CI: 1.3-8.7, P = 0.012). The co-infection adjusted GII attributable fraction was 6.4%. Discussion: Norovirus was a frequent cause of diarrhea in an adult population followed longitudinally in an LMIC setting. Vaccine strategies should consider targeting adults in endemic settings and special populations that could serve as community transmission sources.

本文言語English
論文番号e0131646
ジャーナルPloS one
10
7
DOI
出版ステータスPublished - 2015 7月 10

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • 一般

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