Enzymatic preparation of hollow magnetite microspheres for hyperthermic treatment of cancer

Masakazu Kawashita, Kazuo Sadaoka, Tadashi Kokubo, Takashi Saito, Mikio Takano, Norio Araki, Masahiro Hiraoka

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Ferrimagnetic materials can be expected to be useful as thermal seeds for hyperthermic treatment of cancer, especially where the cancer is located in deep parts of body, as they can generate heat by magnetic hysteretic loss when they are placed in an alternating magnetic field. In this study, hollow magnetite (Fe3O4) particles were prepared using an enzymatic reaction of urease. A hollow particle was obtained by using a Pasteur pipette. The particle was 500 μm in size and was composed of Fe3O 4. Its saturation magnetization and coercive force were 57 emu·g-1 and 183 Oe, respectively. Its heat generation under an alternating magnetic field of 300 Oe at 100 kHz was estimated to be 45 W·g-1. Microspheres 30 μm in diameter were also successfully obtained by using a spray gun.

本文言語English
ページ(範囲)605-610
ページ数6
ジャーナルJournal of Materials Science: Materials in Medicine
17
7
DOI
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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