Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice

Makoto Seo, Ryo Kobayashi, Tetsunori Okamura, Koji Ikeda, Masahiko Satoh, Naoki Inagaki, Hiroichi Nagai, Hisamitsu Nagase

研究成果: Letter査読

2 被引用数 (Scopus)

抄録

Trichloroethylene (TCE) and tetrachloroethylene (perchloroethylene; PCE) are commonly identified as environmental contaminants of groundwater. Previously, we investigated the enhancing effects of TCE and PCE on antigen-induced histamine release and inflammatory mediator production in rat mast cells. In this study, to examine the potential effect of TCE and PCE on antigen-induced histamine release from mouse mast cells, mouse bone marrow-derived mast cells (BMMC) were sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody and then stimulated with DNP-BSA containing with TCE or PCE. Both TCE and PCE significantly enhanced antigen-induced histamine release from BMMC. Next we investigated the effects of TCE and PCE on the passive cutaneous anaphylaxis (PCA) reaction in vivo using ICR mice. TCE and PCE significantly enhanced the PCA reaction in a dose-dependent manner. In addition, we examined the enhancing effects of ingesting small amount of TCE and PCE in drinking water on antigen-stimulated allergic responses. After the ICR mice had ingested TCE or PCE in their drinking water for 2 or 4 weeks, we performed the PCA reaction. Both TCE and PCE ingestion enhanced the PCA reaction in a dose-dependent manner for 4 weeks. These results suggest that exposure to TCE and PCE leads to the augmentation of type I allergic responses in many species.

本文言語English
ページ(範囲)439-445
ページ数7
ジャーナルJournal of Toxicological Sciences
37
2
DOI
出版ステータスPublished - 2012 4月
外部発表はい

ASJC Scopus subject areas

  • 毒物学

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