TY - GEN
T1 - Enhancement of ultrasonic heating with microbubbles and their localization in target tissue
AU - Umemura, Shin Ichiro
AU - Yoshizawa, Shin
AU - Matsumoto, Yoichiro
AU - Sasaki, Kazuaki
AU - Asami, Rei
AU - Kawabata, Ken Ichi
PY - 2009
Y1 - 2009
N2 - The bioeffect of ultrasound can be enhanced by orders of magnitude with microbubbles in a few ways. Enhancement of ultrasonic tissue absorption with a microbubble agent has been demonstrated both in theory and in an in vivo experiment. The ultrasonic power absorbed by a microbubble in its continuous wave response was numerically estimated. It has been predicted that the tissue ultrasonic absorption will be doubled when resonant microbubbles are delivered to the tissue at a concentration in the order of ten bubbles /mm3. An exteriorized murine kidney was exposed to focused ultrasound at 3.2 MHz. With an intravenous bolus administration of 0.2 ml/kg OptisonTM, the ultrasonically induced tissue temperature elevation was multiplied by up to five times. This effect will be useful for therapeutic ultrasound if microbubbles are selectively distributed in the target tissue by ultrasound pulses focused to the tissue. Tissue selective nano-droplets which can be phase-changed to microbubbles by ultrasonic stimulation will be a key to this approach.
AB - The bioeffect of ultrasound can be enhanced by orders of magnitude with microbubbles in a few ways. Enhancement of ultrasonic tissue absorption with a microbubble agent has been demonstrated both in theory and in an in vivo experiment. The ultrasonic power absorbed by a microbubble in its continuous wave response was numerically estimated. It has been predicted that the tissue ultrasonic absorption will be doubled when resonant microbubbles are delivered to the tissue at a concentration in the order of ten bubbles /mm3. An exteriorized murine kidney was exposed to focused ultrasound at 3.2 MHz. With an intravenous bolus administration of 0.2 ml/kg OptisonTM, the ultrasonically induced tissue temperature elevation was multiplied by up to five times. This effect will be useful for therapeutic ultrasound if microbubbles are selectively distributed in the target tissue by ultrasound pulses focused to the tissue. Tissue selective nano-droplets which can be phase-changed to microbubbles by ultrasonic stimulation will be a key to this approach.
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U2 - 10.1109/ULTSYM.2009.5441975
DO - 10.1109/ULTSYM.2009.5441975
M3 - Conference contribution
AN - SCOPUS:77952809611
SN - 9781424443895
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 93
EP - 100
BT - 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2009 IEEE International Ultrasonics Symposium, IUS 2009
Y2 - 20 September 2009 through 23 September 2009
ER -