Enhancement of ultrasonic heating with microbubbles and their localization in target tissue

Shin Ichiro Umemura, Shin Yoshizawa, Yoichiro Matsumoto, Kazuaki Sasaki, Rei Asami, Ken Ichi Kawabata

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

The bioeffect of ultrasound can be enhanced by orders of magnitude with microbubbles in a few ways. Enhancement of ultrasonic tissue absorption with a microbubble agent has been demonstrated both in theory and in an in vivo experiment. The ultrasonic power absorbed by a microbubble in its continuous wave response was numerically estimated. It has been predicted that the tissue ultrasonic absorption will be doubled when resonant microbubbles are delivered to the tissue at a concentration in the order of ten bubbles /mm3. An exteriorized murine kidney was exposed to focused ultrasound at 3.2 MHz. With an intravenous bolus administration of 0.2 ml/kg OptisonTM, the ultrasonically induced tissue temperature elevation was multiplied by up to five times. This effect will be useful for therapeutic ultrasound if microbubbles are selectively distributed in the target tissue by ultrasound pulses focused to the tissue. Tissue selective nano-droplets which can be phase-changed to microbubbles by ultrasonic stimulation will be a key to this approach.

本文言語English
ホスト出版物のタイトル2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
出版社Institute of Electrical and Electronics Engineers Inc.
ページ93-100
ページ数8
ISBN(印刷版)9781424443895
DOI
出版ステータスPublished - 2009
イベント2009 IEEE International Ultrasonics Symposium, IUS 2009 - Rome, Italy
継続期間: 2009 9 202009 9 23

出版物シリーズ

名前Proceedings - IEEE Ultrasonics Symposium
ISSN(印刷版)1051-0117

Other

Other2009 IEEE International Ultrasonics Symposium, IUS 2009
国/地域Italy
CityRome
Period09/9/2009/9/23

ASJC Scopus subject areas

  • 音響学および超音波学

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