Enhancement of radioprotection and anti-tumor immunity by yeast-derived β-glucan in mice

Yeun Hwa Gu, Yasuyuki Takagi, Takashi Nakamura, Takeo Hasegawa, Ikukatsu Suzuki, Masami Oshima, Hitoshi Tawaraya, Yoshimi Niwano

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Intraperitoneal injection of β-glucan was shown to greatly delay mortality in mice exposed to whole-body X-ray radiation and tumor growth in tumor-bearing mice. Since the leukocyte and lymphocyte numbers were increased by a single dose of β-glucan, the radioprotective effect of β-glucan is probably mediated, at least in part, by a hemopoietic action in irradiated mice. In addition, both natural killer (NK) and lymphokine-activated killer (LAK) activities were significantly increased by repeated doses of β-glucan. Augmented immunological activity as seen in increased NK and LAK activity by β-glucan seems to play a role in preventing secondary infections associated with irradiation, and probably contributes to the attenuated tumor growth in tumor-bearing mice through enhanced anti-tumor immunity. These results suggest that β-glucan may be a promising adjunct treatment for cancer patients receiving radiotherapy.

本文言語English
ページ(範囲)154-158
ページ数5
ジャーナルJournal of Medicinal Food
8
2
DOI
出版ステータスPublished - 2005 6月 1

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病

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