Enhancement of mRNA Synthesis from Marek's Disease Virus Genome in the Lymphoblas-toid Cell Line, MDCC-MSB1, by 5-Azacytidine

Masanobu Hayashi, Tatsuya Furuichi, Shaomin Ren, Shigeo Namioka, Emiko Isogai, Meihan Nonoyama

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Marek's disease virus (MDV) DNA in latently infected lymphoblastoid cell lines is considerably methylated. A treatment of the MDV-derived lymphoblastoid cell line, MDCC-MSB1 (MSB1), with 5-azacytidine (5-AzC) resulted in a hypomethylation of MDV DNA and an increase in mRNA from certain portions of the MDV DNA. These results suggest methylation of MDV DNA as being one of the factors associated with a repression of transcription of MDV DNA in the lymphoblastoid cell line, MSB1.

本文言語English
ページ(範囲)305-308
ページ数4
ジャーナルJournal of Veterinary Medical Science
56
2
DOI
出版ステータスPublished - 1994

ASJC Scopus subject areas

  • 獣医学(全般)

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