Enhanced production of vascular endothelial growth factor by human monocytic cells stimulated with endotoxin through transcription factor SP-1

T. Sakuta, K. Matsushita, N. Yamaguchi, T. Oyama, R. Motani, T. Koga, S. Nagaoka, K. Abeyama, I. Maruyama, H. Takada, M. Torii

研究成果: Article査読

32 被引用数 (Scopus)

抄録

The effect of endotoxin on the regulation of vascular endothelial growth factor (VEGF) mRNA expression in human monocytic (THP-1) cells was examined. Endotoxic lipopolysaccharide (LPS) from Escherichia coli and synthetic E. coli-type lipid A (LA-15-PP) enhanced VEGF mRNA expression. LPS-induced VEGF mRNA accumulation was regulated, at least in part, at the transcriptional level. Enhancement of VEGF gene expression by LPS was shown by gel shift analysis and use of transcription factor inhibitors to be mediated via the activation of SP-1.

本文言語English
ページ(範囲)233-237
ページ数5
ジャーナルJournal of Medical Microbiology
50
3
DOI
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 微生物学
  • 微生物学(医療)

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