Engineering a Perfusable Vascular Network in a Microfluidic Device for a Morphological Analysis

Yuji Nashimoto, Yukako Teraoka, Yuichiro Arima, Sanshiro Hanada, Akiko Nakamasu, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

研究成果: Article査読

抄録

Luminal flow in a vascular network delivers nutrients and oxygen to cells in human bodies and applies mechanical stimuli to maintain vascular functions. Although many in vitro vascular models have been developed, there are no reports elucidating the effect of a long-term perfusion in a vascular network. Here, we report two types of microfluidic devices to investigate a vascular remodeling and long-term tissue culture in vitro. We observed formation of angiogenic spouts and a change of the volume of the vascularized tissue model in our microfluidic devices. Our method provides a new platform to study developmental biology with a long-term perfusion.

本文言語English
ページ(範囲)275-280
ページ数6
ジャーナルIEEJ Transactions on Sensors and Micromachines
138
7
DOI
出版ステータスPublished - 2018
外部発表はい

ASJC Scopus subject areas

  • 機械工学
  • 電子工学および電気工学

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