ENDOTHELIN RECEPTORS IN RAT ADRENAL GLAND VISUALIZED BY QUANTITATIVE AUTORADIOGRAPHY

Masahiro Kohzuki, Colin I. Johnston, Siew Yeen Chai, David J. Casley, Fraser Rogerson, Frederick A.O. Mendelsohn

研究成果: Article査読

30 被引用数 (Scopus)

抄録

1. The radioligand [125I]‐endothelin was used to map receptors for endothelin in rat adrenal gland using in vitro autoradiography and computerized densitometry. 2. In the adrenal, a high density of binding was found in the adrenal medulla (binding affinity constant 0.18 ± 0.11 × 109M−1) and zona glomerulosa (binding affinity constant 0.18 ± 0.07 × 109M−1). Binding was low to undetectable in the zona fasciculata and zona reticularis. Unrelated peptides did not displace endothelin. 3. These results provide evidence of endothelin receptor distribution in adrenal gland and suggest that endothelin might exert multiple actions in the adrenal gland on catecholamine and aldosterone biosynthesis and secretion.

本文言語English
ページ(範囲)239-242
ページ数4
ジャーナルClinical and Experimental Pharmacology and Physiology
16
4
DOI
出版ステータスPublished - 1989 4月
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 薬理学
  • 生理学(医学)

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