Enantiospecific Entry to a Common Decalin Intermediate for the Syntheses of Highly Oxygenated Terpenoids

Shota Nagasawa, Kerry E. Jones, Richmond Sarpong

研究成果: Article査読

抄録

Herein, we describe an enantiospecific route to one enantiomer of a common decalin core that is present in numerous highly oxygenated terpenoids. This intermediate is accessed in eight steps from (R)-carvone, an inexpensive, enantioenriched building block, which can be elaborated to the desired bicycle through sequential Fe(III)-catalyzed reductive olefin coupling and Dieckmann condensation. The same synthetic route may be applied to (S)-carvone to afford the enantiomer of this common intermediate for other applications.

本文言語English
ページ(範囲)12209-12215
ページ数7
ジャーナルJournal of Organic Chemistry
84
18
DOI
出版ステータスPublished - 2019 9 20

ASJC Scopus subject areas

  • Organic Chemistry

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