Enantioselective total synthesis of isishippuric acid B via intramolecular michael reaction

Munefumi Torihata, Takashi Nakahata, Shigefumi Kuwahara

研究成果: Article

15 引用 (Scopus)

抜粋

The first enantioselective total synthesis of isishippuric acid B bearing a novel 4,5-seco-6-norquadrane skeleton was accomplished from (R)-citronellal with use of a Diels-Alder cycloaddition and an intramolecular Michael addition as the ring-forming steps. Comparison of the optical rotation of the synthetic material with that of the natural product confirmed the absolute configuration of isishippuric acid B to be 1R, 2R, 8R, and 11R.

元の言語English
ページ(範囲)2557-2559
ページ数3
ジャーナルOrganic letters
9
発行部数13
DOI
出版物ステータスPublished - 2007 6 21

ASJC Scopus subject areas

  • Molecular Medicine

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