Enantioselective Intramolecular Nicholas Reaction Catalyzed by Chiral Phosphoric Acid: Enantioconvergent Synthesis of Seven-Membered Cyclic Ethers from Racemic Diols

研究成果: Article査読

14 被引用数 (Scopus)

抄録

An enantioconvergent intramolecular Nicholas reaction of racemic diols was developed using BINOL- and SPINOL-derived phosphoric acids as the chiral Brønsted acid catalyst. The developed reaction features an efficient approach to the synthesis of seven-membered cyclic ethers in a highly enantioselective manner. Further derivatization of the enantioenriched cyclic ethers, initiated by the de-complexation of the dicobalt species, afforded densely functionalized cyclic ethers having an unsaturated diester moiety without loss of enantiomeric excess.

本文言語English
ページ(範囲)13917-13921
ページ数5
ジャーナルAngewandte Chemie - International Edition
57
42
DOI
出版ステータスPublished - 2018 10 15

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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