Enantioselective copper-catalyzed allylic substitution reaction with aminohydroxyphosphine ligand

Naohiko Yoshikai, Kotaro Miura, Eiichi Nakamura

研究成果: Article査読

29 被引用数 (Scopus)

抄録

A proline-derived aminohydroxyphosphine ligand induced excellent regio- and enantiose-lectivities (SN2′: SN2>94:6, 94-97% ee) in the copper-catalyzed substitution reaction of cinnamyl phosphates with Et2Zn. A computational modelling study of the reaction pathway suggests that the displacement of the leaving group takes place in an ordered, anti-fashion through simultaneous copper-olefin and zinc-oxygen interactions, which is critical for the enantioselection.

本文言語English
ページ(範囲)1014-1018
ページ数5
ジャーナルAdvanced Synthesis and Catalysis
351
7-8
DOI
出版ステータスPublished - 2009 5
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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